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Truvada (tru-VAH-dah) is for use in combination with other HIV medications (such as non-nucleoside reverse transcriptase inhibitors or protease inhibitors) to treat HIV-1 infection in adults.
 Truvada combines two HIV medications, Emtriva® (emtricitabine) and Viread® (tenofovir disoproxil fumarate), into one pill that is taken once a day with or without food.
 Detailed information for healthcare providers is available at Truvada.com
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As part of an HIV regimen, once-a-day Truvada can help get you to undetectable and keep you there.
How does Truvada work?
Truvada is in the
nucleoside reverse transcriptase inhibitor (NRTI or "nuke") family of HIV medicines. Truvada works to lower
viral load by helping to block
reverse transcriptase, a protein that is needed for HIV to multiply (
replicate). To learn more about this once-a-day HIV treatment, visit
Truvada.com.
It is important for anyone taking Truvada to note that Truvada:
- Does not cure HIV infection or AIDS
- Has not been shown to lower your chance of passing HIV to others
- Should only be taken in combination with other drugs for HIV
What is the dosing for Truvada?
The recommended dose of Truvada is one tablet (containing 200 mg of emtricitabine and 300 mg of tenofovir disoproxil fumarate) once a day taken orally with or without food. Truvada should not be used with Atripla™, Emtriva, Viread, Combivir
®, Epivir
®, Epivir-HBV
®, Epzicom™ or Trizivir
®.
See
full Prescribing Information for dose adjustment recommendations in patients with impaired kidney function.
Truvada can be part of a once-a-day regimen
Truvada can be taken with several other HIV medications, specifically
protease inhibitors or non-nucleoside reverse transcriptase inhibitors. For example, the following leading protease inhibitors can be used with Truvada as part of a once-a-day regimen:
Discuss all medicines you take with your healthcare provider and be aware:
- Reyataz may increase the amount of tenofovir disoproxil fumarate (a component of Truvada) in your blood, which could result in more side effects. You may need to be followed more carefully if you are taking Truvada and Reyataz together.
- Kaletra may increase the amount of tenofovir disoproxil fumarate (a component of Truvada) in your blood, which could result in more side effects. You may need to be followed more carefully if you are taking Truvada and Kaletra together.
Indication
TRUVADA is for use in combination with other HIV medications (such as non-nucleoside reverse transcriptase inhibitors or protease inhibitors) to treat HIV-1 infection in adults.
Important Safety Information
• Lactic acidosis (a buildup of acid in the blood) can be a medical emergency and may need to be treated in the hospital. Call your healthcare provider right away if you have nausea, vomiting, unusual muscle pain and/or weakness
• Serious liver problems (hepatotoxicity), with liver enlargement (hepatomegaly) and fat in the liver (steatosis), may occur. Call your healthcare provider right away if you have light-colored stools, dark-colored urine and/or if your skin or the whites of your eyes turn yellow
• Flare-ups of hepatitis B virus (HBV) infection: If you have HIV and HBV, your liver disease may suddenly get worse if you stop taking TRUVADA. Do not stop taking TRUVADA unless directed by your healthcare provider
• Kidney problems: If you have had kidney problems or take other medicines that can cause kidney problems, your healthcare provider should do regular blood tests to check your kidneys
• Bone changes: It is not known whether long-term use of TRUVADA causes damage to your bones. If you have had bone problems in the past, talk to your healthcare provider before taking TRUVADA
Changes in body fat have been seen in some people taking anti-HIV medicines.
The most common side effects of TRUVADA when taken with other anti-HIV medicines are dizziness, diarrhea, nausea, vomiting, headache, abdominal pain, depression, rash and gas. Skin discoloration (spots and freckles) may also occur.
Discuss all medicines you take with your healthcare provider and be aware:
• TRUVADA should not be used with Atripla™, Combivir®, Emtriva, Epivir®, Epivir-HBV®, Epzicom™, Trizivir® or Viread®
• Your healthcare provider may need to follow you more closely or adjust your therapy if you are taking Videx®, Videx EC®, Reyataz® or Kaletra® with TRUVADA
For additional important safety information and details about indication and usage, see the full Prescribing Information.
